HupZ, a Unique Heme-Binding Protein, Enhances Group A Streptococcus Fitness During Mucosal Colonization

Group A Streptococcus (GAS) is a major pathogen that causes simple and invasive infections. GAS requires iron for metabolic processes and pathogenesis, and heme is its preferred iron source. We previously described the iron-regulated hupZ in GAS, showing that a recombinant HupZ-His6 protein binds an...

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Autors principals:	Kristin V. Lyles, Lamar S. Thomas, Corbett Ouellette, Laura C. C. Cook, Zehava Eichenbaum
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2022-06-01
Col·lecció:	Frontiers in Cellular and Infection Microbiology
Matèries:	Group A Streptococcus HupZ heme heme utilization heme toxicity iron
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fcimb.2022.867963/full
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