UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability

Summary: Persistent virus infections can cause pathogenesis that is debilitating or lethal. During these infections, virus-specific T cells fail to protect due to weakened antiviral activity or failure to persist. These outcomes are governed by histone modifications, although it is unknown which enz...

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Autors principals:	Joseph E. Mitchell, Makayla M. Lund, Josh Starmer, Kai Ge, Terry Magnuson, Karl B. Shpargel, Jason K. Whitmire
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2021-04-01
Col·lecció:	Cell Reports
Matèries:	epigenetics histone demethylation CD8+ T cell function persistent infection antiviral defense LCMV
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124721002801
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