Formononetin ameliorates cisplatin-induced hair cell death via activation of the PI3K/AKT-Nrf2 signaling pathway

Cisplatin (CDDP) stands as a highly effective chemotherapeutic agent; however, its ototoxicity remains a perplexing challenge in the field. Formononetin (FMNT), a potent flavonoid isolated from Astragalus membranaceus, displays a diverse range of promising pharmacological activities, encompassing an...

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Autores principales:	Yimeng Li, Jingfang Wu, Huiqian Yu, Xiaoling Lu, Yusu Ni
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2024-01-01
Colección:	Heliyon
Materias:	Formononetin Reactive oxygen species (ROS) Ototoxicity Cisplatin Hair cell Phosphatidylinositol-3-kinase (PI3K)/ serine/threonine kinase 1 (AKT)
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2405844023109583
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