Cascade-targeting copper homeostasis nano-regulators for mild-photothermal boosted cuproptosis/ferroptosis mediated breast cancer therapy

Abstract Inducing cuproptosis in tumor cells is significantly impeded by the challenges of arduous copper ion delivery in vivo and the unbreakable intracellular copper homeostasis, which leads to insufficient mitochondrial copper accumulation. Here, a carrier-free metal-polyphenolic (CF-MPs) based n...

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Auteurs principaux:	Xuejun Liang, Shiji Fang, Yanan Xin, Jingju Lei, Wei Wang, Yi Wei, Wenhui Li, Chaojie Li, Hongchao Tang, Xian Wei, Yanqiang Huang, Lifei Zheng, Yangping Shentu, Xuli Meng, Xin Liu
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-10-01
Collection:	Journal of Nanobiotechnology
Sujets:	Mild-photothermal Cuproptosis Ferroptosis Copper homeostasis GSH depletion
Accès en ligne:	https://doi.org/10.1186/s12951-025-03722-2
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