Potentiation of the antimycobacterial activity of bedaquiline, clofazimine, and doxycycline against Mycobacterium smegmatis by several natural product-based compounds is putatively via efflux inhibition [version 2; peer review: 2 approved, 1 approved with reservations]

Background Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the leading cause of death due to a single infectious pathogen globally. The increasing prevalence of drug-resistant Mtb strains underscores the pressing need for the development of new antimycobacterial drugs...

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Hauptverfasser:	Caroline Maina, Robi Chacha, Eric Guantai, Edwin Murungi, Ephantus Ndirangu, Mathew P. Ngugi, Sospeter Ngoci Njeru, James Mugo, Elizabeth Kigondu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	F1000 Research Ltd 2026-02-01
Schriftenreihe:	Open Research Africa
Schlagworte:	Efflux pumps Mycobacterium smegmatis Mycobacterium tuberculosis molecular docking molecular dynamics efflux inhibition eng
Online-Zugang:	https://openresearchafrica.org/articles/8-23/v2
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