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Crosstalk between endothelial cells and osteoblasts stimulates ALP via Notch signaling and RANKL/OPG ratio independently of Notch signaling in vitro

Abstract Background Bone remodeling requires a complex interplay between osteogenesis and angiogenesis, orchestrated by yet not fully understood intricate signaling pathways in osteoblasts and endothelial cells. Methods In the present study, co-cultures of primary human osteoblasts and human umbilic...

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Bibliografiset tiedot
Päätekijät: Katharina Wirsig, Nina Bürger, Anne Bernhardt
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMC 2025-10-01
Sarja:Cellular & Molecular Biology Letters
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Linkit:https://doi.org/10.1186/s11658-025-00793-9
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