Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes

Abstract Background Histones undergo extensive post-translational modifications and this epigenetic regulation plays an important role in modulating transcriptional programs capable of driving cancer progression. Acetylation of histone H3K18, associated with gene activation, is enhanced by P300 and...

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Bibliografski detalji

Glavni autori:	Shivashankar Damodaran, Nathan Damaschke, Joseph Gawdzik, Bing Yang, Cedric Shi, Glenn O. Allen, Wei Huang, John Denu, David Jarrard
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2017-12-01
Serija:	BMC Cancer
Teme:	Epigenetic modifications in PCa Histone H3 acetylation Cancer progression SIRT2 loss
Online pristup:	http://link.springer.com/article/10.1186/s12885-017-3853-9
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