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Rad52’s DNA annealing activity drives template switching associated with restarted DNA replication

The restart of collapsed replication forks is associated with high rates of genomic rearrangement. Here, the authors show that during restart initiation rearrangements are driven mainly by Rad51, whereas during elongation they rely more on Rad52.

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Detalhes bibliográficos
Principais autores: Anastasiya Kishkevich, Sanjeeta Tamang, Michael O. Nguyen, Judith Oehler, Elena Bulmaga, Christos Andreadis, Carl A. Morrow, Manisha Jalan, Fekret Osman, Matthew C. Whitby
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2022-11-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-022-35060-4
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