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Etoposide-induced protein 2.4 homolog promotes argininosuccinate synthase 1 and cancer cell survival upon arginine deprivation

Abstract Background Arginine auxotrophy has been reported in a subset of cancers with inherently defective de novo arginine synthesis. However, the use of arginine deprivation therapy seems to be unequally effective, partially owing to the resistance acquired by cancer cells. Study of underlying fac...

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Principais autores: Vu T. A. Vo, Le Nhat Tran, Thu Thanh Bui, Han-Woong Lee, Yangsik Jeong
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2025-04-01
Series:Cellular & Molecular Biology Letters
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Acceso en liña:https://doi.org/10.1186/s11658-025-00726-6
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