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Oxidative Stress Is Associated with Neuroinflammation in Animal Models of HIV-1 Tat Neurotoxicity

HIV-1 trans-acting protein Tat, an essential protein for viral replication, is a key mediator of neurotoxicity. If Tat oxidant injury and neurotoxicity have been described, consequent neuroinflammation is less understood. Rat caudate-putamens (CPs) were challenged with Tat, with or without prior rSV...

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Kaydedildi:
Asıl Yazarlar: Jean-Pierre Louboutin, Lokesh Agrawal, Beverly A. S. Reyes, Elisabeth J. Van Bockstaele, David S. Strayer
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2014-05-01
Seri Bilgileri:Antioxidants
Konular:
HIV-1
Tat
oxidative stress
brain
antioxidant enzymes
gene therapy
SV40
neuroinflammation
microglia
astrocytes
Online Erişim:http://www.mdpi.com/2076-3921/3/2/414
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