Inhibition of monkeypox polymerase holoenzyme and methyltransferase using bioactive compounds of black tea: a computational approach

Abstract The WHO declared monkeypox a global health emergency due to its rapid spread. In response, the FDA authorized emergency use of the Jynneos vaccine despite its adverse effects, while smallpox antivirals, repurposed for monkeypox treatment, have shown limited efficacy, highlighting the need f...

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Bibliografische Detailangaben

Hauptverfasser:	Maimoona Mumtaz, Khalid Khan, Asad Khan, Haroon ur Rashid, Ateeq Ullah Jan, Tanzeel Shah, Nasir Ahmad
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-10-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Monkeypox virus Polymerase holoenzyme Methyltransferase Tea bioactives Molecular dynamics simulation
Online-Zugang:	https://doi.org/10.1038/s41598-025-14583-y
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