Investigating the molecular mechanisms associated with ulcerative colitis through the application of single-cell combined spatial transcriptome sequencing

BackgroundUlcerative colitis (UC) is a chronic inflammatory bowel disease marked by dysregulated immune responses, resulting in sustained inflammation and ulceration of the colonic and rectal mucosa. To elucidate the cellular subtypes and gene expression profiles implicated in the pathogenesis of UC...

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Hlavní autoři:	Hua Huang, Jiaze Ma, An Kang, Tianwei Guo, Wei Sun, Yan Xu, Lijiang Ji
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-05-01
Edice:	Frontiers in Immunology
Témata:	immune infiltration single-cell transcriptome sequencing spatial transcriptome sequencing ulcerative colitis T cell exhaustion
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534768/full
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