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Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

Monoacylglycerol lipase (MAGL) is an important enzyme of the endocannabinoid system that catalyzes the degradation of the major endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL is associated with pathological conditions such as pain, inflammation and neurodegenerative diseases like Parkinson’s an...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Vibhu Jha, Marzia Biagi, Valeria Spinelli, Miriana Di Stefano, Marco Macchia, Filippo Minutolo, Carlotta Granchi, Giulio Poli, Tiziano Tuccinardi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-12-01
Schriftenreihe:Molecules
Schlagworte:
virtual screening
MAGL
pharmacophore model
hit identification
Online-Zugang:https://www.mdpi.com/1420-3049/26/1/78
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