The role of neutrophils in the pathophysiology of knee osteoarthritis: a review

Knee osteoarthritis (KOA) is the most prevalent joint disorder, characterized by progressive damage to cartilage, subchondral bone, and other joint-associated tissues. While mechanical stress remains a core driver, evidence increasingly points to immune-mediated mechanisms as modulators/accelerators...

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Bibliografiske detaljer

Principais autores:	Michal Štefančík, Stuart B. Goodman, Jiri Gallo
Format:	Artigo
Sprog:	Inglês
Udgivet:	The British Editorial Society of Bone & Joint Surgery 2026-03-01
Serier:	Bone & Joint Research
Fag:	knee osteoarthritis inflammatory endotype neutrophils synovitis inflammation neutrophil extracellular traps cytokines/chemokines immunophenotyping pathophysiology synovial fluids osteoarthritis (oa) cartilage chondrocytes apoptosis subchondral bone extracellular matrices joint disorder
Online adgang:	https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.153.BJR-2025-0406.R1
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