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Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

ABSTRACT The AAA+ ATPase valosin‐containing protein (VCP/p97) is a central regulator of protein homeostasis that is well characterized for its role in extracting and remodeling ubiquitinated substrates. Dysregulation of VCP activity contributes to the pathogenesis of neurodegenerative diseases and c...

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Principais autores: Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2026-05-01
coleção:Advanced Science
Assuntos:
chemical probes
covalent
cryo‐EM
inhibitors
UTE‐156
valosin‐containing protein
Acesso em linha:https://doi.org/10.1002/advs.202520545
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