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CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1

Background & Aims: Chronic HBV infection is the leading cause of liver disease and of hepatocellular carcinoma. The improvement of antiviral therapy remains an unmet medical need. Capsid assembly modulators (CAMs) target the HBV core antigen (HBc) and inhibit HBV replication. Although CAM-A comp...

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Autori principali: Valerio Taverniti, Laura Meiss-Heydmann, Cloé Gadenne, Hannah Vanrusselt, Dieudonné Buh Kum, Fabio Giannone, Patrick Pessaux, Catherine Schuster, Thomas F. Baumert, Yannick Debing, Eloi R. Verrier
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2024-10-01
Serie:JHEP Reports
Soggetti:
Hepatitis B virus
Capsid assembly modulators
Apoptosis
ANXA1
Annexin A1
Lipocortin I
Accesso online:http://www.sciencedirect.com/science/article/pii/S2589555924001381
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