Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer
The proteasome machinery is a common target of gain-of-function p53 missense mutants. Upregulation of the proteasome fosters chemoresistance to proteasome inhibitors. In triple negative breast cancer cells this resistance mechanism, namely the Nrf2-regulated “bounce-back” response to proteasome inhi...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis Group
2017-01-01
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| coleção: | Molecular & Cellular Oncology |
| Assuntos: | |
| Acesso em linha: | http://dx.doi.org/10.1080/23723556.2016.1217967 |
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