Determining if T cell antigens are naturally processed and presented on HLA class I molecules

Abstract Background Determining T cell responses to naturally processed and presented antigens is a critical immune correlate to determine efficacy of an investigational immunotherapeutic in clinical trials. In most cases, minimal epitopes and HLA restriction elements are unknown. Results Here, we d...

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Hauptverfasser:	Jay Friedman, Sreenivasulu Gunti, Maxwell Lee, Ke Bai, Christian Hinrichs, Clint T. Allen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2022-02-01
Schriftenreihe:	BMC Immunology
Schlagworte:	HLA restriction Antigen presenting cells Minimal epitope Electroporation T cell responses
Online-Zugang:	https://doi.org/10.1186/s12865-022-00478-4
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