ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying mechanisms await further investigation. Here the authors show that selective autophagy regulates NF-κB activation via an ANGPTL8/p62-IKKγ signaling axis.

I tiakina i:

Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua:	Yu Zhang, Xian Guo, Wanyao Yan, Yan Chen, Mengxiang Ke, Cheng Cheng, Xiuqin Zhu, Weili Xue, Qiaoqiao Zhou, Ling Zheng, Shun Wang, Bin Wu, Xinran Liu, Liang Ma, Lianqi Huang, Kun Huang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2017-12-01
Rangatū:	Nature Communications
Urunga tuihono:	https://doi.org/10.1038/s41467-017-02355-w
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!

ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

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