Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9

Abstract Complete removal of hepatitis B virus (HBV) DNA from nuclei is difficult by the current therapies. Recent reports have shown that a novel genome-editing tool using Cas9 with a single-guide RNA (sgRNA) system can cleave the HBV genome in vitro and in vivo. However, induction of a double-stra...

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Autori principali:	Takeshi Kurihara, Takasuke Fukuhara, Chikako Ono, Satomi Yamamoto, Kentaro Uemura, Toru Okamoto, Masaya Sugiyama, Daisuke Motooka, Shota Nakamura, Masato Ikawa, Masashi Mizokami, Yoshihiko Maehara, Yoshiharu Matsuura
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2017-07-01
Serie:	Scientific Reports
Accesso online:	https://doi.org/10.1038/s41598-017-05905-w
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