Proanthocyanidins delaying the premature ovarian insufficiency through regulatory sirt1-p53-p21 signaling pathway in female germline stem cells

Abstract Background As women age, their ovarian follicle pool naturally declines. However, female germline stem cells (FGSCs) possess a unique ability to differentiate into oocytes and continuously self-renew, providing an effective means of delaying ovarian aging by replenishing the primordial foll...

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Autors principals:	Wenbo Wu, Mengying Bai, Wenli Hong, Shuyi Ling, Yuan Li, Yuqing Dai, Ruoxin Weng, Haifeng Wu, Chongyang Ren, Liujuan Zhang, Ziqiong Zhou, Zhisheng Zhong, Xinxin Fu, Yuehui Zheng
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-05-01
Col·lecció:	Journal of Ovarian Research
Matèries:	Proanthocyanidins Female germline stem cells Silent information regulator 1 Premature ovarian insufficiency Mice
Accés en línia:	https://doi.org/10.1186/s13048-025-01661-y
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