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Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo.

In Parkinson's and Alzheimer's diseases, the allocortex accumulates aggregated proteins such as synuclein and tau well before neocortex. We present a new high-throughput model of this topographic difference by microdissecting neocortex and allocortex from the postnatal rat and treating them in paral...

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Auteurs principaux: Jessica M Posimo, Amanda M Titler, Hailey J H Choi, Ajay S Unnithan, Rehana K Leak
Format: Artigo
Langue:Inglês
Publié: Public Library of Science (PLoS) 2013-01-01
Collection:PLoS ONE
Accès en ligne:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23536801/?tool=EBI
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