Synthesis, Antibacterial and Antiribosomal Activity of the 3<i>C</i>-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-<i>O</i>-Ribofuranosyl Apramycins)

The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-<i>O</i>-(5-amino-3-<i>C</i>-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported. Both anomers show excellent activity for the inhibition of bacterial ribosomes and that of MRSA and various wild-...

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Autors principals:	Dmitrijs Lubriks, Klara Haldimann, Sven N. Hobbie, Andrea Vasella, Edgars Suna, David Crich
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-12-01
Col·lecció:	Antibiotics
Matèries:	aminoglycoside modifying enzymes ribosomal methyltransferases antibacterials antiribosomal activity aminoglycoside antibiotics
Accés en línia:	https://www.mdpi.com/2079-6382/12/1/25
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