DDX54 drives ALKBH5-mediated demethylation of selected transcripts to suppress interferon antiviral response

ABSTRACT DEAD-box (DDX) proteins are currently reported to shape host innate immunity by regulation of N6-methyladenosine (m6A) modification of transcripts for host factors involved in antiviral signaling. However, which DDX proteins are involved in antiviral response remains incompletely understood...

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Hauptverfasser:	Hao-Yu Sun, Xiu-Ying Gong, Zi-Ling Qu, Li-Li An, Wen-Hao Guo, Hong-Yu Luan, Meng-Yao Wu, Ji-Cheng Yu, Cheng Dan, Yi-Bing Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2025-09-01
Schriftenreihe:	Journal of Virology
Schlagworte:	DEAD-box helicase 54 ALKBH5 demethylation activity interferon response substrate selectivity
Online-Zugang:	https://journals.asm.org/doi/10.1128/jvi.00507-25
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