Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition

Chronic intermittent hypoxia (CIH), the main attribute of obstructive sleep apnea (OSA), produces oxidative stress, endothelial dysfunction, and hypertension. Nitric oxide (NO) plays a critical role in controlling the vasomotor tone. The NO level depends on the L-arginine level, which can be reduced...

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Principais autores:	Bernardo J. Krause, Paola Casanello, Ana C. Dias, Paulina Arias, Victoria Velarde, German A. Arenas, Marcelo D. Preite, Rodrigo Iturriaga
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-07-01
coleção:	Frontiers in Physiology
Assuntos:	arginase chronic intermittent hypoxia endothelial dysfunction nitric oxide oxidative stress vascular reactivity
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphys.2018.00901/full
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