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Activation of Nrf2/HO-1 Pathway and Human Atherosclerotic Plaque Vulnerability: An In Vitro and In Vivo Study

Reactive oxygen species (ROS) induce nuclear factor erythroid 2–related factor 2 (Nrf2) activation as an adaptive defense mechanism, determining the synthesis of antioxidant molecules, including heme-oxygenase-1 (HO-1). HO-1 protects cells against oxidative injury, degrading free heme and inhi...

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Tallennettuna:
Päätekijät: Susanna Fiorelli, Benedetta Porro, Nicola Cosentino, Alessandro Di Minno, Chiara Maria Manega, Franco Fabbiocchi, Giampaolo Niccoli, Francesco Fracassi, Simone Barbieri, Giancarlo Marenzi, Filippo Crea, Viviana Cavalca, Elena Tremoli, Sonia Eligini
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI AG 2019-04-01
Sarja:Cells
Aiheet:
oxidative stress
nuclear factor erythroid 2–related factor 2
heme-oxygenase-1
macrophages
plaque vulnerability
optical coherence tomography
Linkit:https://www.mdpi.com/2073-4409/8/4/356
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