HPLC-MS/MS coupled with equilibrium dialysis method for quantification of free drug concentration of pazopanib in plasma

Background: The selective occurrence of hepatotoxicity observed with use of pazopanib may be attributed to its high level of plasma protein binding and low hepatic extraction ratio. The primary objective was to investigate changes in free drug concentration amongst patients with varying albumin conc...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Yi Long Toh, Yi Yun Pang, Maung Shwe, Ravindran Kanesvaran, Chee Keong Toh, Alexandre Chan, Han Kiat Ho
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2020-04-01
Edice:	Heliyon
Témata:	Pazopanib Plasma free drug concentration Fraction unbound Liquid chromatography-tandem mass spectrometry Equilibrium dialysis Pharmacology
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2405844020306587
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!