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3D-STED Super-Resolution Microscopy Reveals Distinct Nanoscale Organization of the Hematopoietic Cell-Specific Lyn Substrate-1 (HS1) in Normal and Leukemic B Cells

HS1, the hematopoietic homolog of cortactin, acts as a versatile actin-binding protein in leucocytes. After phosphorylation, it is involved in GTPase and integrin activation, and in BCR, TCR, and CXCR4 downstream signaling. In normal and leukemic B cells, HS1 is a central cytoskeletal interactor and...

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Principais autores: Marta Sampietro, Moreno Zamai, Alfonsa Díaz Torres, Veronica Labrador Cantarero, Federica Barbaglio, Lydia Scarfò, Cristina Scielzo, Valeria R. Caiolfa
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-06-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
HS1
CLL
B cells
super-resolution
STED
phasor-FLIM
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2021.655773/full
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