De novo non-canonical nanopore basecalling enables private communication using heavily-modified DNA data at single-molecule level

Abstract Hidden messages in DNA molecules by employing chemical modifications has been suggested for private data storage and transmission at high information density. However, rapidly decoding these “molecular keys” with corresponding basecallers remains challenging. We present DeepSME, a nanopore...

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Detalhes bibliográficos

Principais autores:	Qingyuan Fan, Xuyang Zhao, Junyao Li, Ronghui Liu, Ming Liu, Qishun Feng, Yanping Long, Yang Fu, Jixian Zhai, Qing Pan, Yi Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-05-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-59357-2
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