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Inhibition of NOS1 promotes the interferon response of melanoma cells

Abstract Background NOS1 expression predicts poor prognosis in patients with melanoma. However, the molecular function of NOS1 in the type I IFN response and immune escape of melanoma is still unknown. Methods The CRISPR/Cas9 system was used to generate NOS1-knockout melanoma cells and the biologica...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Xi Chen, Zhiwei Zou, Qianli Wang, Wenwen Gao, Sisi Zeng, Shuangyan Ye, Pengfei Xu, Mengqiu Huang, Keyi Li, Jianping Chen, Zhuo Zhong, Qianbing Zhang, Bingtao Hao, Qiuzhen Liu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2022-05-01
Schriftenreihe:Journal of Translational Medicine
Schlagworte:
CRISPR/Cas9
Bioinformatics
NOS1
Metabolism
Interferon
Melanoma
Online-Zugang:https://doi.org/10.1186/s12967-022-03403-w
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