Humanized APOE mouse brain volume increases over age irrespective of sex and APOE genotype: implications for translational validity to the human
BackgroundHumanized APOE mouse models are widely used to study late-onset Alzheimer’s disease (LOAD) risk, yet it remains unclear whether they reproduce the macrostructural brain changes observed in human aging and disease.MethodsWe performed ex vivo magnetic resonance imaging to quantify total and...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Frontiers Media S.A.
2026-07-01
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| Σειρά: | Frontiers in Neuroscience |
| Θέματα: | |
| Διαθέσιμο Online: | https://www.frontiersin.org/articles/10.3389/fnins.2026.1843319/full |
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