Low frequency and rare coding variants affect susceptibility and progression of childhood acute lymphoblastic leukemia

Abstract This study aimed to explore the potential genetic underpinnings of childhood acute lymphoblastic leukemia (ALL). Initially, an exome-wide association analysis of 89 ALL survivors and 356 controls was conducted to identify candidate genes, incorporating single-variant tests and annotation-we...

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Autores principales:	Xiao Liu, Ru Zhang, Heng Zhang, Junyi Xin, Huiqin Li, Yongchu Pan, Liwen Zhu, Meiyun Kang, Hua Jiang, Yongjun Fang, Yao Xue, Mulong Du
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2026-01-01
Colección:	Cancer Cell International
Materias:	Acute lymphoblastic leukemia Exome-wide association study Rare variant Clinical phenomics Survivorship
Acceso en línea:	https://doi.org/10.1186/s12935-025-04128-8
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