Conserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors

Entry of HIV-1 into target cells is mediated by its envelope (Env) glycoprotein composed of the receptor binding subunit gp120 and the fusion protein gp41. Refolding of the gp41 N- and C-terminal heptad repeats (NHR and CHR) into a six-helix bundle (6-HB) conformation drives the viral and cellular m...

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Detalhes bibliográficos

Principais autores:	Xiuzhu Geng, Zixuan Liu, Danwei Yu, Bo Qin, Yuanmei Zhu, Sheng Cui, Huihui Chong, Yuxian He
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2019-07-01
coleção:	Viruses
Assuntos:	HIV-1 gp41 membrane fusion six-helical bundle fusion inhibitor
Acesso em linha:	https://www.mdpi.com/1999-4915/11/7/609
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