Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways

We performed a transcriptomic analyses using the strategies we pioneered and made the following findings: 1) Normal lymphoid Tregs, diseased kidney Tregs, splenic Tregs from mice with injured muscle have 3, 17 and 3 specific (S-) pathways, respectively; 2) Tumor splenic Tregs share 12 pathways with...

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Autori principali:	Dong Ni, TingTing Tang, Yifan Lu, Keman Xu, Ying Shao, Fatma Saaoud, Jason Saredy, Lu Liu, Charles Drummer, Yu Sun, Wenhui Hu, Jahaira Lopez-Pastrana, Jin J. Luo, Xiaohua Jiang, Eric T. Choi, Hong Wang, Xiaofeng Yang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2021-05-01
Serie:	Frontiers in Immunology
Soggetti:	CD4+Foxp3+ regulatory T cells (Treg) canonical secretome innate immune caspase-1 dependent secretome innate immune caspase-4/11 dependent secretome immune checkpoint receptors
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.678201/full
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