Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
The mammalian target of rapamycin (mTOR) regulates cell growth and survival by integrating nutrient and hormonal signals. These signaling functions are distributed between at least two distinct mTOR protein complexes: mTORC1 and mTORC2. mTORC1 is sensitive to the selective inhibitor rapamycin and ac...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science (PLoS)
2009-02-01
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| Col·lecció: | PLoS Biology |
| Accés en línia: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19209957/pdf/?tool=EBI |
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