An Epigenetic Basis for Sustained Inflammatory Epithelial Progenitor Cell States in Crohn’s DiseaseSummary

Background & Aims: Defining consequential differences in intestinal epithelial stem cells in healthy humans vs those with inflammatory bowel disease (Crohn’s disease and ulcerative colitis) is essential for the development of much needed therapies to restore the epithelial barrier and maintain i...

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Principais autores:	Tatiana A. Karakasheva, Clara Morral Martinez, Yusen Zhou, Jingya Qui, Xinyi E. Chen, Gloria E. Soto, Shaneice K. Nettleford, Olivia T. Hix, Daana M. Roach, Alyssa M. Laguerta, Anusha Thadi, Rachael M. Edwards, Daniel Aleynick, Sarah Weinbrom, Elizaveta Borodyanskaya, Oliver H. Pickering, MaryKate Fulton, Chia-Hui Chen, Isabella V. Peterson, Erik B. Hagen, Ian P. Yannuzzi, Zainab Haider, Zvi Cramer, Maire A. Conrad, Ning Li, Meenakshi Bewtra, Yasin Uzun, Kai Tan, Judith R. Kelsen, Andy J. Minn, Christopher J. Lengner, Kathryn E. Hamilton
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2026-01-01
Serija:	Cellular and Molecular Gastroenterology and Hepatology
Teme:	Chronic Inflammation Colonoids Crohn's Disease Enteroids Inflammatory Bowel Disease Intestinal Stem Cells
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2352345X25002061
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