Efficient differentiation of human primordial germ cells through geometric control reveals a key role for Nodal signaling

Human primordial germ cells (hPGCs) form around the time of implantation and are the precursors of eggs and sperm. Many aspects of hPGC specification remain poorly understood because of the inaccessibility of the early postimplantation human embryo for study. Here, we show that micropatterned human...

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Autors principals:	Kyoung Jo, Seth Teague, Bohan Chen, Hina Aftab Khan, Emily Freeburne, Hunter Li, Bolin Li, Ran Ran, Jason R Spence, Idse Heemskerk
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2022-04-01
Col·lecció:	eLife
Matèries:	human pluripotent stem cells cell fate patterning primordial germ cells cell signaling micropatterning
Accés en línia:	https://elifesciences.org/articles/72811
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