Non-classical immune checkpoint CD137/CD137L and CD200/CD200R expressions are regulated by the tumor immune microenvironment in lymph node aspirates from lung cancer patients

BackgroundImmune escape is a hallmark of lung cancer, and limited responsiveness to PD-1/PD-L1 blockade highlights the need to identify additional immunoregulatory mechanisms in the mediastinal tumor microenvironment (TME). Non-classical immune checkpoints, including CD137/CD137L and CD200/CD200R, m...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Iwona Kwiecień, Agata Raniszewska-Borys, Elżbieta Rutkowska, Rafał Sokołowski, Karina Jahnz-Różyk, Piotr Rzepecki
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-05-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	CD137/CD137L CD200/CD200R EBUS/TBNA flow cytometry immune checkpoints lung cancer
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1766726/full
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