Distinct roles for interleukin-23 receptor signaling in regulatory T cells in sporadic and inflammation-associated carcinogenesis

IntroductionThe pro-inflammatory cytokine interleukin-23 (IL-23) has been implicated in colorectal cancer (CRC). Yet, the cell-specific contributions of IL-23 receptor (IL-23R) signaling in CRC remain unknown. One of the cell types that highly expresses IL-23R are colonic regulatory T cells (Treg ce...

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Principais autores:	Justin Jacobse, Jennifer M. Pilat, Jing Li, Rachel E. Brown, Aaron Kwag, Matthew A. Buendia, Yash A. Choksi, M. Kay Washington, Christopher S. Williams, Nicholas O. Markham, Sarah P. Short, Jeremy A. Goettel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-02-01
Colecção:	Frontiers in Oncology
Assuntos:	colorectal carcinoma interleukin-23 regulatory T cells inflammation-associated cancer sporadic cancer macrophages
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1276743/full
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