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miR‐21 sustains CD28 signalling and low‐affinity T‐cell responses at the expense of self‐tolerance

Abstract Objective miR‐21 is highly expressed in iNKT and activated T cells, but its T‐cell autonomous functions are poorly defined. We sought to investigate the role of miR‐21 in the development and functions of T and iNKT cells, representing adaptive and innate‐like populations, respectively. Meth...

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Bibliografiset tiedot
Päätekijät: Maya Fedeli, Mirela Kuka, Annamaria Finardi, Francesca Albano, Valentina Viganò, Matteo Iannacone, Roberto Furlan, Paolo Dellabona, Giulia Casorati
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Wiley 2021-01-01
Sarja:Clinical & Translational Immunology
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Linkit:https://doi.org/10.1002/cti2.1321
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