Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages

ABCA1 exports excess cholesterol from cells to apoA-I and is essential for HDL synthesis. Genetic studies have shown that ABCA1 protects against cardiovascular disease. We have previously shown that the interaction of apoA-I with ABCA1 activates signaling molecule Janus kinase 2 (JAK2), which optimi...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Chongren Tang, Barbara A. Houston, Carl Storey, Renee C. LeBoeuf
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2016-05-01
Serier:	Journal of Lipid Research
Fag:	inflammation high density lipoprotein apolipoprotein A-I ATP binding cassette transporter A1 signal transducer and activator of transcription 3 suppressor of cytokine signaling 3
Online adgang:	http://www.sciencedirect.com/science/article/pii/S0022227520309871
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!