Cytoplasmically Retargeted HSV1-tk/GFP Reporter Gene Mutants for Optimization of Noninvasive Molecular-Genetic Imaging

To optimize the sensitivity of imaging HSV1-tk/GFP reporter gene expression, a series of HSV1-tk/GFP mutants was developed with altered nuclear localization and better cellular enzymatic activity, compared to that of the native HSV1-tk/GFP fusion protein (HSVi-tk/GFP). Several modifications of HSV1-...

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Principais autores:	Vladimir Ponomarev, Michael Doubrovin, Inna Serganova, Tatiana Beresten, Jelena Vider, Aleksander Shavrin, Ludmila Ageyeva, Julius Balatoni, Ronald Blasberg, Juri Gelovani Tjuvajev
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2003-05-01
叢編:	Neoplasia: An International Journal for Oncology Research
主題:	molecular imaging herpes virus type one thymidine kinase green fluorescent protein FIAU PET
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S1476558603800568
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