mRNA ratios of AR to ESR1 and PGR distinguish breast cancer subtypes based on public datasets and experimental models

Abstract The role of the androgen receptor (AR) in breast cancer (BC) remains incompletely understood. Here, we conducted a meta-analysis of large-scale microarray transcriptomic datasets to evaluate whether the mRNA expression levels of the androgen receptor gene, relative to those of the estrogen...

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Detalhes bibliográficos
Main Authors: Diego Prieto, Milena Rondón-Lagos, Paola Cruz-Tapias, Andrés Rincón-Riveros, Wilson Rubiano, Jairo De la Peña, Elizabeth Vargas, Victoria E. Villegas, Nelson Rangel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-07-01
Colecção:Scientific Reports
Assuntos:
Breast cancer
Molecular subtypes
Androgen receptor
Estrogen receptor
Progesterone receptor
Meta-analysis
Acesso em linha:https://doi.org/10.1038/s41598-025-06856-3
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