Targeting and dissociating HIF2α from the molecular chaperone Hsp70 triggers apoptosis in kidney cancer

Abstract Background The transcription factor Hypoxia-Inducible Factor 2α (HIF2α) plays a crucial role in cancer cell adaptation to hypoxic conditions, particularly in clear cell renal cell carcinoma, promoting tumor growth and angiogenesis. Targeting HIF2α through pharmacologic inhibition offers a p...

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主要な著者:	Jennifer A. Heritz, Sarah J. Backe, Angela Pacherille, Sara J. Cayaban, Michael F. Basin, Britannia Smith, Rebecca A. Sager, Michael Daneshvar, Dawn E. Post, Mark R. Woodford, Dimitra Bourboulia, John D. Chisholm, Mehdi Mollapour, Gennady Bratslavsky
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2026-01-01
シリーズ:	Communications Medicine
オンライン･アクセス:	https://doi.org/10.1038/s43856-025-01356-x
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