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PTEN: multiple functions in human malignant tumors

PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor suppressor in a PI3K-independent manner. Indeed, the PTEN network regulates a broad spectrum of biological functions, modu...

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Principais autores: Michele eMilella, Italia eFalcone, Fabiana eConciatori, Ursula eCesta Incani, Anais eDel Curatolo, Nicola eInzerilli, Carmen C.M.A. Nuzzo, Vanja eVaccaro, Sabrina eVari, Francesco eCognetti, Ludovica eCiuffreda
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015-02-01
Serier:Frontiers in Oncology
Fag:
Cancer
Pten
Subcellular localization
PI3K
PHTS
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00024/full
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