Pentagalloyl glucose suppresses MSU crystal–induced gout inflammation and arachidonic acid production in vitro and in vivo

BackgroundGout is an acute inflammatory arthritis triggered by monosodium urate (MSU) crystal deposition and activation of innate immune responses. In addition to inflammasome signaling, emerging evidence suggests that metabolic reprogramming of arachidonic acid (AA) pathways amplifies inflammatory...

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Hauptverfasser:	Sadiq Umar, Yu Lu, Sugasini Dhavamani, Poorna C. R. Yalagala, Mateusz S. Wietecha, Sriram Ravindran
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-04-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	arachidonic acid pathway inflammation macrophages MSU-gout model pentagalloyl glucose
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1812913/full
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