Dorsal raphe nucleus–hippocampus serotonergic circuit underlies the depressive and cognitive impairments in 5×FAD male mice

Abstract Background Depressive symptoms often occur in patients with Alzheimer's disease (AD) and exacerbate the pathogenesis of AD. However, the neural circuit mechanisms underlying the AD-associated depression remain unclear. The serotonergic system plays crucial roles in both AD and depression. M...

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Главные авторы:	Meiqin Chen, Chenlu Wang, Yinan Lin, Yanbing Chen, Wenting Xie, Xiaoting Huang, Fan Zhang, Congrui Fu, Kai Zhuang, Tingting Zou, Dan Can, Huifang Li, Shengxi Wu, Ceng Luo, Jie Zhang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2024-07-01
Серии:	Translational Neurodegeneration
Предметы:	Alzheimer’s disease Depressive symptoms Cognitive impairment 5-HT neurons Dorsal raphe nucleus Dorsal hippocampal CA1
Online-ссылка:	https://doi.org/10.1186/s40035-024-00425-w
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