Recombinant rat heat shock protein 70 (rrHSP70) may promote remyelination by regulating microglia/macrophages and oligodendrocytes in a toxin-induced demyelination animal model

Heat shock protein 70 (HSP70) can assemble with other extracellular matrix proteins to form deoxycholate-insoluble aggregates in multiple sclerosis (MS) lesions, impairing oligodendrocyte (OLG) maturation and remyelination. However, soluble HSP70 supports myelination. HSP70 may also promote bone mar...

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Autors principals:	Jian Song, Jiayan Wang, Yuanzhi Li, Hui Wang, Mei Li, Fei Huang, Xiaoming Zhang, Ding Wan, Jiahao Ye, Keyu Zhou, Lu Yang, Haining Li, Chun Zhang, Tao Sun, Qiaofeng Wan, Shaozhang Hou, Changseng Leng, Peng Wang
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-07-01
Col·lecció:	Frontiers in Immunology
Matèries:	multiple sclerosis (MS) oligodendrocytes (OLGs) phagocytosis of microglia and macrophages recombinant rat heat shock protein 70 (rrHSP70) remyelination
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1750555/full
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