Non-hematopoietic erythropoietin splice variant is produced in the diseased human brain and confers neuroprotection

Erythropoietin (EPO) is a pleiotropic cytokine with important functions in neuronal development and neuroprotection, but hematopoietic effects limit the therapeutic application of EPO in neurological diseases. We discovered human endogenous EPO splice variants that are non-hematopoietic but cytoprot...

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Autori principali:	Theresa Hartung, Dorette Freyer, Anne Zemella, Helena Radbruch, January Weiner, Jasmin Jamal El-Din, Andreas Meisel, Josef Priller
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-01-01
Serie:	Frontiers in Cellular Neuroscience
Soggetti:	alternative splicing cell-free glycoprotein synthesis erythropoietin in situ hybridization neuroprotection oxygen glucose deprivation
Accesso online:	https://www.frontiersin.org/articles/10.3389/fncel.2025.1677505/full
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