β-Dystroglycan Restoration and Pathology Progression in the Dystrophic <i>mdx</i> Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation

ROS-activated cSrc tyrosine kinase (TK) promotes the degradation of β-dystroglycan (β-DG), a dystrophin-glycoprotein complex component, which may reinforce damaging signals in Duchenne muscular dystrophy (DMD). Therefore, cSrc-TK represents a promising therapeutic target. In <i>mdx</i> mice, a 4-wee...

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Autors principals:	Paola Mantuano, Brigida Boccanegra, Elena Conte, Michela De Bellis, Santa Cirmi, Francesca Sanarica, Ornella Cappellari, Ilaria Arduino, Annalisa Cutrignelli, Angela Assunta Lopedota, Antonietta Mele, Nunzio Denora, Annamaria De Luca
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2021-11-01
Col·lecció:	Biomolecules
Matèries:	Duchenne muscular dystrophy preclinical study <i>mdx</i> mouse dasatinib cyclodextrin oral formulation
Accés en línia:	https://www.mdpi.com/2218-273X/11/11/1742
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